(1. 重慶理工大學(xué) 材料科學(xué)與工程學(xué)院，重慶 400054；
2. 重慶市特種焊接材料與技術(shù)高校工程研究中心，重慶 400054)
摘 要: 鎂及鎂合金由于其良好的生物相容性和可降解性能，在生物醫(yī)用材料領(lǐng)域具有巨大的應(yīng)用潛力。然而，過快的降解速率限制了其臨床應(yīng)用。羥基磷灰石(HA)涂層具有良好的骨誘導(dǎo)性和骨傳導(dǎo)性，可以有效地延緩鎂及鎂合金的腐蝕速率。但是，單一的羥基磷灰石涂層不能滿足鎂基植入物的使用壽命要求，因此需對(duì)其進(jìn)一步的改性。本文從生物相容性、可降解性以及力學(xué)性能等方面綜述鎂合金表面以羥基磷灰石為基礎(chǔ)，以高分子材料、無機(jī)材料以及離子摻雜而成的可降解鎂基HA復(fù)合涂層的發(fā)展和研究現(xiàn)狀。
關(guān)鍵字: 鎂合金；羥基磷灰石；復(fù)合涂層；生物材料
（1. School of Materials Science & Engineering, Chongqing University of Technology, Chongqing 400054, China;
2. Chongqing Municipal Engineering Research Center of Institutions of Higher Education for Special Welding Materials and Technology, Chongqing 400054, China）
Abstract:Magnesium and magnesium alloys have great potential as biomedical materials due to their good biocompatibility and biodegradability. However, the rapid degradation rate limits their clinical application. Hydroxyapatite (HA) coating has good osteoinductivity and osteoconductivity, which can delay the corrosion of magnesium alloy to some extent. But a single hydroxyapatite coating cannot meet the requirements for the clinical service life of magnesium implants, so the HA coating needs to be further modification. In this paper, the research and development about biocompatibility, biodegradability and mechanical properties of HA composite coating modified by polymer, ceramic and doped-ions on magnesium and its alloys were reviewed.
Key words: magnesium alloy; hydroxyapatite; composite coating; biomaterials
