(1. 山東科技大學(xué) 材料科學(xué)與工程學(xué)院，青島 266510;
2. 重慶理工大學(xué) 材料科學(xué)與工程學(xué)院，重慶 400050)
摘 要: 由于鎂及其合金具有良好的生物相容性和力學(xué)相容性，降低鎂合金過(guò)快的腐蝕速度成為其作為生物材料應(yīng)用的關(guān)鍵，醫(yī)用鎂合金表面改性已成為新一代生物材料的研究重點(diǎn)。介紹醫(yī)用鎂合金的發(fā)展歷程，重點(diǎn)討論鎂合金表面生物活性陶瓷(如羥基磷灰石(HA))、陽(yáng)極氧化膜、可降解高分子聚合物(如聚乳酸(PLA)、PLGA、殼聚糖)、惰性生物陶瓷涂層(如TiO2、Al2O3、ZrO2)、化學(xué)轉(zhuǎn)化膜(氟化膜、稀土轉(zhuǎn)化膜)和金屬鍍層(如Ti、Zn)制備、耐蝕性及其生物相容性，并指出其發(fā)展趨勢(shì)。
關(guān)鍵字: 鎂合金；生物材料；生物涂層；腐蝕；生物相容性
magnesium alloys for medical applications
（1. College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266510, China;
2. School of Materials Science and Engineering, Chongqing University of Technology, Chongqing 400050, China）
Abstract:Magnesium and its alloys have excellent biocompatibility and mechanical compatibility. The reduction in their rapid corrosion rates becomes the key to clinical applications. The current study on magnesium alloys as biomaterials is focused on the surface modification. The history and recent cutting edge researches on the bio-coatings on medical magnesium alloys were predominately reviewed. The emphasis was placed on the recent progress of the preparation, corrosion resistance and biocompatibility of the bio-coatings. These coatings include hydroxyaptite (HA), micro arc oxidation films or plasma electrolyte oxidation coatings, degradable polymers (polylactic acid (PLA), poly (lactide-co- glycolide) (PLGA) and chitosan), inert bio-ceramic coatings (TiO2, Al2O3 and ZrO2) and chemical conversion films (fluoride and rare earth) and ion implanted titanium and zinc films as well. The developmental trends were proposed.
Key words: magnesium alloy; biomaterials; bio-coating; corrosion; biocompatibility
