(武漢工業(yè)大學(xué) 生物材料與工程研究中心, 武漢 430070)
摘 要: 用Ca(OH)2飽和溶液在超聲波作用下制備出穩(wěn)定的羥基磷灰石溶膠 (HAP-sol)。X射線衍射，TEM和電子衍射測試表明溶膠中的HAP由針狀微晶組成。體外細(xì)胞培養(yǎng)實驗發(fā)現(xiàn)HAP-sol對W-256癌肉瘤細(xì)胞和艾氏腹水瘤細(xì)胞的增殖均具有較強的抑制作用，HAP-sol與上述瘤細(xì)胞接觸24 h后其半數(shù)有效抑制濃度分別為189 mg /L 和210 mg/L。
關(guān)鍵字: 羥基磷灰石溶膠；瘤細(xì)胞；半數(shù)有效抑制濃度
（Biomedical Materials and Engineering Center, Wuhan University of Technology, Wuhan 430070, P.R.China）
Abstract:The Hydroxyapatite-sol(HAP-sol) was synthesized by ultrasonic irradiation. The detections of XRD, TEM and electron diffraction showed that the hydroxyapatite in HAP-sol consisted of needle-like microcrystals. The cell culture experiments in vitro indicated that HAP-sol strongly inhibited the proliferation of W-256 and Aishi abdomen sarcoma cells. Its half effective inhibition concentrations were 189 mg/L and 210 mg/L respectively after HAP-sol was in contact of 24 h with tumour cell.
Key words: hydroxyapatite-sol; tumour cell; half effective inhibition concentration
