(武漢工業(yè)大學(xué)生物材料與工程研究中心，武漢 430070
湖北醫(yī)科大學(xué)附屬二醫(yī)院，武漢 430071)
摘 要: 用羥基磷灰石(Ca10(PO4)6(OH)2，簡稱HA)和對照材料鈦合金制備了經(jīng)皮元件試樣，并將試樣穿皮植入受試動物背部皮內(nèi)進(jìn)行實驗。通過分期對植入局部皮膚組織形態(tài)學(xué)觀察，就材料對皮膚組織的炎性反應(yīng)和表皮向下生長情況進(jìn)行了對照研究。結(jié)果表明：鈦合金材料周圍組織局部慢性炎性細(xì)胞浸潤，輕度充血和水腫，有嚴(yán)重的表皮向下生長；HA材料周圍組織未 明顯炎性細(xì)胞浸潤，各觀察期均無顯著的表皮向下生長，材料與皮膚組織結(jié)合緊密，組織相容性良好。
關(guān)鍵字: 經(jīng)皮元件 羥基磷灰石(HA) 炎性反應(yīng) 表皮向下生長 組織相容性
（Biomedical Materials and Engineering Research Centre,
Wuhan University of Technology, Wuhan 430070, P. R. China
The Second Affiliated Hospital,Hubei Medical University, Wuhan 430071, P. R. China）
Abstract:The samples of percutaneous device were made of hydroxyapatite (HA) and comparison material, and were percutaneously implanted in the back skin of the animals for experiments. Through histomorphology observations by stages on part skin tissue, the inflammation and the downgrowth of epidermis caused by the materials were comparatively studied. The results demonstrated that part tissue surrounding Ti alloy have chronic inflammatory cells infiltration, slight hyperemia and oedema. Downgrowth of the epidermis is serious, in the case of HA neither clear inflammatory cells infiltration nor marked downgrowth of the epidermis was observed in every observation stage. The material bind tightly with skin tissue. The histocompatibility of HA for percutaneous device is fine.
Key words: percutaneous device; hydroxyapatite; inflammation; epidermis downgrowth; histocompatibility
