李世普1, 賀建華1, 余國榮2
(1. 武漢理工大學(xué) 生物材料與工程研究中心,
武漢 430070；
2. 武漢大學(xué) 中南醫(yī)院, 武漢 430072)
摘 要: 磷酸鈣（α-TCP/TTCP）復(fù)合骨水泥具有良好的水硬性能， 與固化液按固液比為1.50g/mL拌和后， 凝固時間可調(diào)， 抗壓強(qiáng)度達(dá)45.36MPa， 其水化產(chǎn)物為羥基磷灰石（HAP）。 通過體外模擬溶解實(shí)驗表明, α-TCP/TTCP骨水泥具有一定的溶解性能。通過體外實(shí)驗、 動物實(shí)驗， 結(jié)合SEM和EPMA觀察表明α-TCP/TTCP骨水泥不會產(chǎn)生全身或局部毒性反應(yīng)，對肌肉無刺激， 不致溶血、 凝血， 不引起炎癥和排斥反應(yīng)等， 有利于骨組織長入并與骨組織緊密接觸。 α-TCP/TTCP骨水泥在動物體內(nèi)可繼續(xù)水化硬化，且隨著植入時間的延長， 材料與宿主骨完全融合在一起。 α-TCP/TTCP骨水泥具有優(yōu)良的生物相容性和生物活性， 具有一定的降解性能和較好的成骨作用，適合于作為骨缺損的填充材料。
關(guān)鍵字: 磷酸鈣骨水泥； 生物相容性； 生物活性
bone cement
LI Shi-pu1, HE Jian-hua1, YU Guo-rong2
（1. Biomedical Materials and Engineering Center, Wuhan University of Technology,Wuhan 430070, China;
2. Zhongnan Hospital, Wuhan University,Wuhan 430072, China）
Abstract:α-tricalcium phosphate(α-TCP)/tetracalcium phosphate(TTCP) composite bone cement (CPC) has good hydration characteristic. CPC powder mixture is mixed with water at a powder/liquid (P/L) ratio of 1.50g/mL. The setting time can be adjusted, the maximal compressive strength is 45.36MPa, and the hydration product is hydroxyapatite (HAP). In vitro biological simulated experiments indicate that α-TCP/TTCP bone cement has certain dissolubility. The hardened product is mainly HAP after soaking in simulated body fluid (SBF) for 10 weeks. The results of in vitro test and animal experiments and SEM analyses show that no local or general toxicity response, no muscle stimulation, no haemolysis, no cruor and no inflammatory reaction, no exclusion response are caused by α-TCP/TTCP cement, which contributes to bone tissue spreading and impinging. α-TCP/TTCP cement hydrates and hardens continually in vivo. The materials fuse with host bone together with implanting time prolonging. α-TCP/TTCP composite bone cement has good biocompatibility and bioactivity, certain biodegradation and good osteogenesis as well. It is qualified as an artificial bone material.
Key words: calcium phosphate bone cement; biocompatibility; bioactivity
